About viruses and viral disease
Mon, 10 Dec 2018 20:40:21 +0000
Trial By Error: And Cochrane Makes Another Move…
By David Tuller, DrPH Yet another interesting development has taken place at Cochrane—and this new development again suggests that things there might be moving in the right direction. On Friday, the organization withdrew a protocol for what is called an “individual patient data” review of exercise therapy for the illness it has referred to as […]
Mon, 10 Dec 2018 20:40:21 +0000
TWiV 523: Virology in Zürich
At the University of Zürich, Vincent speaks with virologists Cornel Fraeful, Urs Greber, and Silke Stertz about their careers and their work on AAV2, adenovirus entry, and influenza virus. <span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”></span><span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”></span>&lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; […]
Sun, 09 Dec 2018 14:24:32 +0000
Trial By Error: How BMJ Enabled Bristol’s Ethics Exemptions
By David Tuller, DrPH Earlier today, I sent the following e-mail to Dr Fiona Godlee, editorial director of BMJ. I cc’d Carol Monaghan MP, Darren Jones MP, and Nicky Morgan MP. I also cc’d Teresa Allen of the Health Research Authority. ********** Dear Dr. Godlee— As you know, I have spent some time criticizing a […]
Tue, 04 Dec 2018 19:49:07 +0000
Trial By Error: Some Good News on Cochrane
By David Tuller, DrPH In what can only be characterized as a welcome surprise, Cochrane has rejected the revision of a 2014 review of exercise treatments for chronic fatigue syndrome, stating that the work does not meet the organization’s “quality standards.” Cochrane revealed the decision late Friday in a statement appended to the review, which […]
Mon, 03 Dec 2018 18:58:17 +0000
TWiV 522: Readers of the lost ORF
The TWiVsters review isolation of a naturally occurring DNA virus from fruit flies, and the cell-type specific function of a small transmembrane protein encoded in an open reading frame upstream of the enterovirus polyprotein. <span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”></span><span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”></span>&lt;span […]
Sun, 02 Dec 2018 16:17:23 +0000
The lost picornavirus ORF
For over 50 years the RNA genome of picornaviruses (illustrated below for poliovirus) was thought to be translated into a single, long polyprotein. All this time a very small upstream open reading frame (uORF) has gone undetected – until now. Analysis of over 3000 picornavirus genomes revealed a small ORF, beginning with an AUG codon, […]
Fri, 30 Nov 2018 03:45:50 +0000
TWiV 521: Spitting in the Allee
Team TWiV cover the discovery of another giant virus from 30,000 year old Siberian permafrost, and how viral aggregation accelerates the production of new infectious viruses and increases fitness, demonstrating an Allee effect. <span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”></span><span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”></span> Click […]
Sun, 25 Nov 2018 14:38:26 +0000
Paul Has Measles
Susana López, Martha Yocupicio, Selene Zárate, virologists from Mexico, together with graphic illustrator Eva Lobatón, have teamed up to produce Paul Has Measles, a children’s book about viruses and vaccines. Paul Has Measles is available in English (download link) or Spanish (download link). Please share!
Wed, 21 Nov 2018 02:50:38 +0000
Trial By Error: Some Thoughts About NICE
By David Tuller, DrPH The UK’s National Institute for Health and Care Excellence (NICE), which develops clinical guidelines for a range of medical conditions, is currently selecting a committee to develop a new guidance for the illness it refers to as myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). The new guidance will replace one written in 2007, […]
Mon, 19 Nov 2018 19:52:18 +0000
Small Things Considered
A blog for sharing appreciation of the width and depth of microbes and microbial activities on this planet.
It Comes With The Terroir
by Roberto | There is something very special about wine, at least for my taste. I do, however, admit to the possibility that many of our readers will wonder what's the big deal about the beverage, it's just fermented grape juice after all.
Talmudic Question #160
Why are obligate endosymbionts of insects (for example, Buchnera ) more often mutualistic but those of vertebrates (for example, Rickettsia ) more often parasitic?
by Elio et al. | For as long as I can remember, I have been fascinated by the subject of symbiosis. This is one of the grand themes in biology, what Margaret McFall-Ngai has aptly called 'the elephant in the room', deserving much love and attention. But exactly, what is it that is so fascinating about it?
"May I ask you a question?"
by Elio | My first lecture (in 1958, long ago) was to medical students and the subject was DNA. I felt privileged to be given the task to talk about this subject, which was born in its modern incarnation not many years earlier.
Replay : A Close Encounter of the Enological Kind
by John Ingraham | Early in my career, by good fortune, I encountered the malolactic fermentation. Investigating it by standard microbiological methods led to results that changed the way California red wines are made, for the better most agree. How satisfying it is to think that I was following in the footsteps of Pasteur, no less, and his early career...
To Retract or Not to Retract… That’s the Question
In the previous post I discussed  that editors of Science asked for the retraction of a paper linking XMRV retrovirus to ME/CFS. The decision of the editors was based on the failure of at least 10 other studies to confirm these findings and on growing support that the results were caused by contamination. When the authors refused […]
Tue, 07 Jun 2011 13:34:25 +0000
Science Asks to Retract the XMRV-CFS Paper, it Should Never Have Accepted in the First Place.
Wow! Breaking! As reported in WSJ earlier this week , editors of the journal Science asked Mikovits and her co-authors to voluntary retract their 2009 Science paper . In this paper Mikovits and colleagues of the Whittemore Peterson Institute (WPI) and the Cleveland Clinic, reported the presence of xenotropic murine leukemia virus–related virus (XMRV) in peripheral blood mononuclear cells […]
Thu, 02 Jun 2011 21:34:34 +0000
Does the NHI/FDA Paper Confirm XMRV in CFS? Well, Ditch the MR and Scratch the X… and… you’ve got MLV.
The long awaited paper that would ‘solve’ the controversies about the presence of Xenotropic Murine Leukemia Virus-related virus (XMRV) in patients with chronic fatigue syndrome (CFS) was finally published in PNAS last week . The study, a joint effort of the NIH and the FDA, was withheld, on request of the authors , because it contradicted […]
Mon, 30 Aug 2010 03:32:21 +0000