About viruses and viral disease
Sun, 24 Jul 2016 14:56:41 +0000
TWiV 399: Zika la femme
The latest Zika virus news from the ConTWiVstadors, including a case of female to male transmission, risk of infection at the 2016 summer Olympics, a DNA vaccine, antibody-dependent enhancement by dengue antibodies, and sites of replication in the placenta. You can find TWiV #399 at microbe.tv/twiv, or listen below. Click arrow to play Download TWiV 399 (75 […]
Sun, 24 Jul 2016 14:56:41 +0000
A herpesvirus associated with female infertility
Viruses that replicate in the male or female reproductive tract are considered to be potential causes of human infertility. Several herpesviruses have been implicated in male infertility, and now human herpesvirus 6A (HHV-6A) has been found in endometrial cells of women with unexplained infertility (paper link). HHV-6 was only recently discovered (1986) and is now known […]
Thu, 21 Jul 2016 20:01:13 +0000
TWiV 398: Permission to be intuitive
Vincent speaks with Sandy Weller about her career and her work on the mechanisms of synthesis, maturation, cleavage and packaging of viral DNA genomes.
Sun, 17 Jul 2016 13:07:16 +0000
Congress fails on Zika virus
Andrew W. Gurman, M.D., President of the American Medical Association, has expressed disappointment in the failure of Congress to support the US public health response to Zika Virus: At a time when concerns continue to mount about the nation’s readiness to protect the public from the Zika virus, the AMA is disappointed by Congress’ failure to pass legislation before […]
Fri, 15 Jul 2016 02:15:35 +0000
TWiV 397: Trial by error
Journalism professor David Tuller returns to TWiV for a discussion of the PACE trial for ME/CFS: the many flaws in the trial, why its conclusions are useless, and why the data must be released and re-examined. You can find TWiV #397 at microbe.tv/twiv, or listen below. Click arrow to play Download TWiV 397 (67 MB .mp3, 93 […]
Sun, 10 Jul 2016 12:45:23 +0000
TWiV 396: Influenza viruses with Peter Palese
Vincent speaks with Peter Palese about his illustrious career in virology, from early work on neuraminidases to universal influenza virus vaccines, on episode #396 of the science show This Week in Virology. You can find TWiV #396 at microbe.tv/twiv, or listen below. Click arrow to play Download TWiV 396 (54 MB .mp3, 74 min) Subscribe (free): iTunes, RSS, email
Sun, 03 Jul 2016 21:35:18 +0000
Do giant viruses have a CRISPR-like immune system or a protein restriction factor?
A battle is brewing between two research groups in Marseille, France that are involved in the discovery and study of giant viruses. Didier Raoul and colleagues believe that they have discovered a CRISPR-like, DNA based defense system in mimivirus that confers resistance to virophage (paper link). Claverie and Abergel disagree: they think that the defense […]
Thu, 30 Jun 2016 13:53:22 +0000
TWiV 395: The cancer thief
Vincent, Rich and Kathy speak with Stephen Russell about his career and his work on oncolytic virotherapy – using viruses to treat cancers. Recorded before an audience at ASV 2016 at Virginia Tech in Blacksburg, Virginia. You can find TWiV #395 at microbe.tv/twiv, or listen/view below. Click arrow to play Download TWiV 395 (44 MB .mp3, 60 min) Subscribe (free): iTunes, RSS, email, Google Play Music Become a patron of TWiV!
Sun, 26 Jun 2016 21:44:32 +0000
TWiV 394: Cards in a hand
Vincent and Alan speak with Erica Ollmann Saphire about her career and her work on understanding the functions of proteins of Ebolaviruses, Marburg virus, and other hemorrhagic fever viruses, at ASM Microbe 2016 in Boston, MA. You can find TWiV #394 at microbe.tv/twiv, or listen or watch the video below. Click arrow to play Download TWiV […]
Sun, 19 Jun 2016 10:28:48 +0000
Small Things Considered
A blog for sharing appreciation of the width and depth of microbes and microbial activities on this planet.
A Special Issue
by ElioI have long enjoyed the journal Nature Microbiology2016-07-27T23:17:00-07:00
Black Death for Corals:The Polymicrobial Pathogenesis of Black Band Disease
by Daniel P. Haeusser | This June Disney released the anticipated Pixar Animation Studios sequel Finding Dory to earn the largest animated film opening receipts in North America ever. The popularity of the original Finding Nemo in 2003 led to reportedly increased demand for clownfish like Nemo for pets; some concerned environmentalists worry that...
Talmudic Question #135
"Invasive species" is a common topic among plant and animal ecologists. Why is it not much used in the context of microbial diversity?
Pictures Considered #38. A Molecular Stiletto
by Christoph Weigel | Imagine you equip your standard E. coli cells with a few additional genes, conveniently placed on plasmids and under control of inducible promoters. You grow the cells and induce the expression of these additional genes. Not long after, the cytoplasm of the cells turns reddish, when looked at under the fluorescence microscope, due to...
by Michael Malamy | For at least twenty years now I have given a few lectures with discussion sections on the early papers of Benzer on rII, followed by the exploitation of the rII system by Crick, Brenner and their colleagues to study the nature of mutations arising spontaneously or after treatment with mutagenic agents, the nature of the genetic code...
To Retract or Not to Retract… That’s the Question
In the previous post I discussed  that editors of Science asked for the retraction of a paper linking XMRV retrovirus to ME/CFS. The decision of the editors was based on the failure of at least 10 other studies to confirm these findings and on growing support that the results were caused by contamination. When the authors refused […]
Tue, 07 Jun 2011 13:34:25 +0000
Science Asks to Retract the XMRV-CFS Paper, it Should Never Have Accepted in the First Place.
Wow! Breaking! As reported in WSJ earlier this week , editors of the journal Science asked Mikovits and her co-authors to voluntary retract their 2009 Science paper . In this paper Mikovits and colleagues of the Whittemore Peterson Institute (WPI) and the Cleveland Clinic, reported the presence of xenotropic murine leukemia virus–related virus (XMRV) in peripheral blood mononuclear cells […]
Thu, 02 Jun 2011 21:34:34 +0000
Does the NHI/FDA Paper Confirm XMRV in CFS? Well, Ditch the MR and Scratch the X… and… you’ve got MLV.
The long awaited paper that would ‘solve’ the controversies about the presence of Xenotropic Murine Leukemia Virus-related virus (XMRV) in patients with chronic fatigue syndrome (CFS) was finally published in PNAS last week . The study, a joint effort of the NIH and the FDA, was withheld, on request of the authors , because it contradicted […]
Mon, 30 Aug 2010 03:32:21 +0000