About viruses and viral disease
Fri, 26 Aug 2016 01:18:17 +0000
Animal viruses with separately packaged RNA segments
There are many examples of viruses with segmented genomes – like influenza viruses – but these genomes segments are packaged in one virus particle. Sometimes the genome segments are separately packaged in virus particles. Such multicomponent viruses are commonly found to infect plants and fungi, but only recently have examples of such viruses that infect animals […]
Fri, 26 Aug 2016 01:18:17 +0000
TWiV 403: It’s not easy being vaccine
The TWiV team takes on an experimental plant-based poliovirus vaccine, contradictory findings on the efficacy of Flumist, waning protection conferred by Zostavax, and a new adjuvanted subunit zoster vaccine. You can find TWiV #403 at microbe.tv/twiv, or listen below. Click arrow to play Download TWiV 403 (70 MB .mp3, 96 min) Subscribe (free): iTunes, RSS, email Become a patron of TWiV!
Tue, 23 Aug 2016 19:53:35 +0000
Whole plant cells producing viral capsid protein as a poliovirus vaccine candidate
Although the use of the live, attenuated (Sabin) poliovirus vaccines has been instrumental in nearly eradicating the virus from the planet, the rare reversion to virulence of these strains has lead to the World Health Organization to recommend their replacement with inactivated poliovirus vaccine (IPV). Unfortunately IPV is also not without shortcomings, including high cost, failure […]
Fri, 19 Aug 2016 04:05:41 +0000
TWiV 402: The plight of the bumblebee
Polio returns to Nigeria, Zika virus spreads in Miami, and virus infection of plants attracts bumblebees for pollination, from the virus gentlepeople at TWiV. You can find TWiV #400 at microbe.tv/twiv, or listen below. Click arrow to play Download TWiV 402 (85 MB .mp3, 118 min) Subscribe (free): iTunes, RSS, email Become a patron of TWiV!
Sun, 14 Aug 2016 14:22:44 +0000
Volatile organic compounds that are emitted by plants – which play important roles in attracting insects – can be altered by virus infection. Infection by cucumber mosaic virus (CMV) increases the emissions that attract aphids, but the virus-altered plant juices are not so tasty, so the insect quickly leaves to spread virus to other plants (listen to […]
Fri, 12 Aug 2016 01:28:17 +0000
Zika Virus in the USA
On this episode of Virus Watch we cover three Zika virus stories: the first human trial of a Zika virus vaccine, the first local transmission of infection in the United States, and whether the virus is a threat to participants in the 2016 Summer Olympic and Paralympic Games.
Mon, 08 Aug 2016 15:13:33 +0000
TWiV 401: Vector victorious
Zika virus spreads in the USA, a Zika virus DNA vaccine goes into phase I trials, and how mosquito bites enhance virus replication and disease, from the friendly TWiFolk Vincent, Dickson, Alan, and Kathy. You can find TWiV #401 at microbe.tv/twiv, or listen below. Click arrow to play Download TWiV 401 (86 MB .mp3, 119 min) Subscribe (free): iTunes, RSS, email Become a patron of TWiV!
Sun, 07 Aug 2016 12:38:36 +0000
Mosquito saliva enhances virus replication and disease
Mosquito saliva, which is injected into the host as a mosquito probes for a blood vessel, contains a collection of chemicals which include anticoagulants to prevent blood clotting, vasodilators to keep blood vessels wide, and anesthetics to prevent us from sensing the mosquito. Saliva also contains components that enhance viral replication, dissemination, and pathogenesis by […]
Fri, 05 Aug 2016 01:29:59 +0000
TWiV 400: Harold ‘400’ Varmus, a scientist for all seasons
The TWiV team is together in New York City for a conversation with Nobel Laureate Harold Varmus about his remarkable career in science. You can find TWiV #400 at microbe.tv/twiv, or listen/watch below. Click arrow to play Download TWiV 400 (101 MB .mp3, 139 min) Subscribe (free): iTunes, RSS, email Become a patron of TWiV!
Sun, 31 Jul 2016 14:58:37 +0000
To Retract or Not to Retract… That’s the Question
In the previous post I discussed  that editors of Science asked for the retraction of a paper linking XMRV retrovirus to ME/CFS. The decision of the editors was based on the failure of at least 10 other studies to confirm these findings and on growing support that the results were caused by contamination. When the authors refused […]
Tue, 07 Jun 2011 13:34:25 +0000
Science Asks to Retract the XMRV-CFS Paper, it Should Never Have Accepted in the First Place.
Wow! Breaking! As reported in WSJ earlier this week , editors of the journal Science asked Mikovits and her co-authors to voluntary retract their 2009 Science paper . In this paper Mikovits and colleagues of the Whittemore Peterson Institute (WPI) and the Cleveland Clinic, reported the presence of xenotropic murine leukemia virus–related virus (XMRV) in peripheral blood mononuclear cells […]
Thu, 02 Jun 2011 21:34:34 +0000
Does the NHI/FDA Paper Confirm XMRV in CFS? Well, Ditch the MR and Scratch the X… and… you’ve got MLV.
The long awaited paper that would ‘solve’ the controversies about the presence of Xenotropic Murine Leukemia Virus-related virus (XMRV) in patients with chronic fatigue syndrome (CFS) was finally published in PNAS last week . The study, a joint effort of the NIH and the FDA, was withheld, on request of the authors , because it contradicted […]
Mon, 30 Aug 2010 03:32:21 +0000