About viruses and viral disease
Fri, 15 Feb 2019 00:34:30 +0000
A portal for RNA exit
Virus particles are metastable: they must be highly stable, to protect the nucleic acid while traveling from host to host or cell to cell, and then come apart to liberate the genome into the cell. New insight into this uncoating process comes from beautiful images of feline calicivirus showing formation of a portal on the […]
Fri, 15 Feb 2019 00:34:30 +0000
Trial By Error: Spotila’s Take on NIH Grant Reviewers
By David Tuller, DrPH Because of various developments in the UK and elsewhere, I’ve neglected goings-on back home. I’m working on a couple of things now but in the meantime I decided to post something typically insightful that Jennie Spotila published last week on her blog, Occupy M.E. It’s a frustration with this project that […]
Thu, 14 Feb 2019 03:40:58 +0000
Trial By Error: Re-visiting My Questions for PACE Professors
By David Tuller, DrPH I thought it might be helpful to re-post a list of questions I wanted to ask Professor White and his PACE colleagues in September, 2015–more than a month before Virology Blog posted the first installment of “Trial By Error: The Troubling Case of the PACE Chronic Fatigue Syndrome Study.” I originally […]
Wed, 13 Feb 2019 15:23:21 +0000
Trial By Error: BMJ Amends Last Week’s PACE Article
By David Tuller, DrPH Added Feb 12: I realized today that I wanted to add a couple of details. The new version of the BMJ article about the Health Research Authority analysis of PACE includes this sentence at the bottom: “Correction notice: On 8 February 2019 a new version of this article was posted with […]
Tue, 12 Feb 2019 05:17:28 +0000
TWiV 534: Portal to the METTL
The TWiV crew reveal a unique portal on the calcivirus capsid formed upon receptor engagement, and the regulation of interferon responses in virus-infected cells by methylation of mRNA. Click arrow to play Download TWiV 534 (57 MB .mp3, 95 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv
Sun, 10 Feb 2019 17:24:17 +0000
Inter-kingdom interactions in the mosquito gut
The gut tracts of many animals are inhabited by a microbial community composed of bacteria, archaea, fungi, and viruses. The interplay among these inhabitants can have an impact on health and disease. Mosquitoes are no exception – replication of dengue virus in the gut tract is modulated by a fungus and a bacterium. When female […]
Thu, 07 Feb 2019 20:31:16 +0000
Trial By Error: HRA Report Does Not Vindicate PACE
By David Tuller, DrPH Last week, I reported that Bristol University had launched an independent investigation of research led by Professor Esther Crawley, at the request of the the UK Health Research Authority. Today, the HRA released a report on the PACE trial that has portrayed it as a well-conducted study. GET/CBT supporters are framing […]
Wed, 06 Feb 2019 23:49:26 +0000
Trial By Error: And Another Prebuttal…
By David Tuller, DrPH Update: Since posting this several hours ago, I have learned that the story I’ve been “prebutting” is not in fact likely to appear imminently; I suppose that means it could be weeks before publication. I’m not sure whether I misinterpreted the reporter’s statement that obtaining my response to the “harassment” claims […]
Tue, 05 Feb 2019 16:11:31 +0000
Trial By Error: A Recap of the School Absence Study
By David Tuller, DrPH Last week I broke the news that Bristol University is conducting an independent investigation of a number of studies that were exempted from ethical review on the grounds that they qualified as “service evaluation.” Because the issues involved are confusing and complex, I thought it would be helpful to repost here […]
Sun, 03 Feb 2019 13:51:53 +0000
Small Things Considered
A blog for sharing appreciation of the width and depth of microbes and microbial activities on this planet.
Nano Pétanques – A Snippet
by Christoph | "The power of evolution is revealed through the diversity of life." Aha! It was solemnly declared by the Nobel Prize committee in their statement announcing last year's chemistry prizes for "the directed evolution of enzymes [and] phage display of peptides and antibodies". Royal academies – national or other academies likewise – tend to add luster...
Inside Earth, Microbes Approach Immortality
by Jennifer Frazer | Last December, the Deep Carbon Observatory announced an astounding fact: the mass of the microbes living beneath Earth's surface amounts to 15 to 23 billion tons of carbon, a sum some 245 to 385 times greater than the carbon mass of all humans. That's amazing. It wasn't so long ago we weren't even sure life at depth was possible.
The Fires of Saint Anthony – A Snippet
by RobertoJust recently, after giving a very general public lecture on microbes, the discussion went – not surprisingly – in the direction of humans and our relationships to our microbiota.
by Jamie | Long, long ago, some two billion years, when earthlings were represented solely by prokaryotes, there existed dense microbial mats, bustling with activity and with metabolic sophistication to match the most advanced engineering of eukaryotic metropolises of today. Included in the mats were many types of bacteria alongside their "oddball" brethren, members of the Archaea family. Like any complex community of entities with varied interests, there was friction, there was war, there were truces, there was stealing, and sometimes there was cooperation.
Dental Care for Your Pet: For Their Health and Yours
by Meaghan O’Neill | Ever since the domestication of wolves, humans have probably remarked upon the particularly bad breath that our dog companions frequently display. Medieval illuminated bestiaries speculated that the strong odor from a wolf’s mouth could betray his presence to prey – like a flock of sheep – causing the wolf to its make approach from downwind.
To Retract or Not to Retract… That’s the Question
In the previous post I discussed  that editors of Science asked for the retraction of a paper linking XMRV retrovirus to ME/CFS. The decision of the editors was based on the failure of at least 10 other studies to confirm these findings and on growing support that the results were caused by contamination. When the authors refused […]
Tue, 07 Jun 2011 13:34:25 +0000
Science Asks to Retract the XMRV-CFS Paper, it Should Never Have Accepted in the First Place.
Wow! Breaking! As reported in WSJ earlier this week , editors of the journal Science asked Mikovits and her co-authors to voluntary retract their 2009 Science paper . In this paper Mikovits and colleagues of the Whittemore Peterson Institute (WPI) and the Cleveland Clinic, reported the presence of xenotropic murine leukemia virus–related virus (XMRV) in peripheral blood mononuclear cells […]
Thu, 02 Jun 2011 21:34:34 +0000
Does the NHI/FDA Paper Confirm XMRV in CFS? Well, Ditch the MR and Scratch the X… and… you’ve got MLV.
The long awaited paper that would ‘solve’ the controversies about the presence of Xenotropic Murine Leukemia Virus-related virus (XMRV) in patients with chronic fatigue syndrome (CFS) was finally published in PNAS last week . The study, a joint effort of the NIH and the FDA, was withheld, on request of the authors , because it contradicted […]
Mon, 30 Aug 2010 03:32:21 +0000