About viruses and viral disease
Thu, 19 Jan 2017 20:52:22 +0000
A viral nucleus
A unique feature of eukaryotic cells, which distinguishes them from bacteria, is the presence of a membrane-bound nucleus that contains the chromosomal DNA (illustrated; image credit). Surprisingly, a nucleus-like structure that forms during viral infection of bacteria is the site of viral DNA replication (link to paper). During infection of Pseudomonas bacteria with the phage 2O1phi2-1, a […]
Thu, 19 Jan 2017 20:52:22 +0000
Emerging Pathogen Surveillance with Jonna Mazet
I spoke with Jonna Mazet, PhD, UC Davis School of Veterinary Medicine, about emerging pathogen surveillance and public health. Dr. Mazet is the Principal Investigator and Global Director of the novel viral emergence early warning project, PREDICT, that has been developed with the US Agency for International Development’s (USAID) Emerging Pandemic Threats Program. Recorded at the Emerging […]
Tue, 17 Jan 2017 19:25:15 +0000
TWiV 424: FLERVergnügen
Trudy joins the the TWiVlords to discuss new tests for detecting prions in the blood, and evidence showing that foamy retroviruses originated in the seas with their jawed vertebrate hosts at least 450 million years ago. You can find TWiV #424 at microbe.tv/twiv, or listen below. Click arrow to play Download TWiV 424 (67 MB .mp3, 111 min) […]
Sun, 15 Jan 2017 17:06:21 +0000
Building an Ebola Virus Lab in Sierra Leone with Ian Goodfellow
I spoke with virologist Ian Goodfellow, whose laboratory works on noroviruses, about why he went to Sierra Leone to establish an Ebolavirus diagnostic and sequencing laboratory. The obstacles he encountered were considerable, but the results were very useful. Recorded at the Emerging Infectious Diseases A to Z (EIDA2Z) conference hosted by the National Emerging Infectious Diseases Laboratories (NEIDL).
Fri, 13 Jan 2017 16:25:48 +0000
A blood test for prion disease
A sensitive and specific blood test has been developed that could be used to limit the risk of transmission of prion disease through the blood supply (link to papers one and two). Prion diseases, also known as spongiform encephalopathies, are uniformly fatal, chronic degenerative neurological diseases caused by misfolding of a cellular protein, PrPC. Transmissible […]
Fri, 13 Jan 2017 01:58:06 +0000
TWiV 423: Dry, well formed, and light brown
The TWiV academia discuss induction of diarrhea by the capsid protein of an astrovirus, and association of a fungal RNA virus with white-nose syndrome of North American bats. You can find TWiV #423 at microbe.tv/twiv, or listen below. Click arrow to play Download TWiV 423 (66 MB .mp3, 110 min) Subscribe (free): iTunes, RSS, email Become a patron of TWiV!
Sun, 08 Jan 2017 18:15:44 +0000
Giving your neighbor the gift of virus susceptibility
Virus infections initiate when virions bind to receptors on the cell surface. It is well known that cells can be made susceptible to infection by providing DNA encoding the virus receptor. For example, mice cannot be infected with poliovirus, but become susceptible if they are given the human poliovirus receptor gene. Now we have learned that providing the receptor protein […]
Thu, 05 Jan 2017 22:42:53 +0000
Interview with Harmit Malik
Vincent Racaniello interviews Harmit Malik, PhD, Fred Hutchinson Cancer Research Center. Harmit and his laboratory are interested in a variety of problems that are characterized by evolutionary conflict. This video is one of 26 video interviews with eminent virologists that are part of the supplemental material for Principles of Virology, 4th Edition, published by ASM Press. […]
Thu, 05 Jan 2017 02:13:37 +0000
TWiV 422: Watching the icosahedron drop
The TWiVestigators wrap up 2016 with a discussion of the year’s ten compelling virology stories. You can find TWiV #422 at microbe.tv/twiv, or listen below. Click arrow to play Download TWiV 422 (71 MB .mp3, 117 min) Subscribe (free): iTunes, RSS, email Become a patron of TWiV!
Sun, 01 Jan 2017 18:14:44 +0000
Small Things Considered
A blog for sharing appreciation of the width and depth of microbes and microbial activities on this planet.
Talmudic Question #141
How come peptides made enzymatically (independent of ribosomes) don't seem to get strung together to make a respectably sized protein?
TWiM #143: E-scaffolds and receptor transfer
On This Week in Microbiology: The use of an electrochemical gradient to eliminate bacterial biofilms, and how phage susceptibility can be transferred by exchange of receptor proteins.
Do bacterial species really exist and why should we care?
by Kostas Konstantinidis and Roberto Kolter | The second part of the question in the title of this post is relative easy to answer; the first part is much more challenging. Defining bacterial species is not only an important academic exercise but also has major practical consequences. For example, infectious disease diagnoses, regulations involving the transport of bacteria, and educating the public regarding bacteria that are beneficial to humans, animals or plants are all deeply-rooted in naming bacterial species.
The Ecology of Louis Pasteur
by Elio | Pasteur is as close to being the father of our science as it gets, with Robert Koch a close contender. Both made fundamental contributions, best remembered for their elucidation of the microbial origin of infectious diseases. The two came to it from rather different points of view and the contrast between them...
Microbial Reading Roundup
by Daniel P. Haeusser | Today I wanted to catch up with some recent books that visitors to this blog may have interest in adding to their microbiological library. So here is a roundup of six academic microbial titles of note that make up a trio of related pairs.
To Retract or Not to Retract… That’s the Question
In the previous post I discussed  that editors of Science asked for the retraction of a paper linking XMRV retrovirus to ME/CFS. The decision of the editors was based on the failure of at least 10 other studies to confirm these findings and on growing support that the results were caused by contamination. When the authors refused […]
Tue, 07 Jun 2011 13:34:25 +0000
Science Asks to Retract the XMRV-CFS Paper, it Should Never Have Accepted in the First Place.
Wow! Breaking! As reported in WSJ earlier this week , editors of the journal Science asked Mikovits and her co-authors to voluntary retract their 2009 Science paper . In this paper Mikovits and colleagues of the Whittemore Peterson Institute (WPI) and the Cleveland Clinic, reported the presence of xenotropic murine leukemia virus–related virus (XMRV) in peripheral blood mononuclear cells […]
Thu, 02 Jun 2011 21:34:34 +0000
Does the NHI/FDA Paper Confirm XMRV in CFS? Well, Ditch the MR and Scratch the X… and… you’ve got MLV.
The long awaited paper that would ‘solve’ the controversies about the presence of Xenotropic Murine Leukemia Virus-related virus (XMRV) in patients with chronic fatigue syndrome (CFS) was finally published in PNAS last week . The study, a joint effort of the NIH and the FDA, was withheld, on request of the authors , because it contradicted […]
Mon, 30 Aug 2010 03:32:21 +0000