About viruses and viral disease
Thu, 30 Jun 2016 13:53:22 +0000
Do giant viruses have a CRISPR-like immune system or a protein restriction factor?
A battle is brewing between two research groups in Marseille, France that are involved in the discovery and study of giant viruses. Didier Raoul and colleagues believe that they have discovered a CRISPR-like, DNA based defense system in mimivirus that confers resistance to virophage (paper link). Claverie and Abergel disagree: they think that the defense […]
Thu, 30 Jun 2016 13:53:22 +0000
TWiV 395: The cancer thief
Vincent, Rich and Kathy speak with Stephen Russell about his career and his work on oncolytic virotherapy – using viruses to treat cancers. Recorded before an audience at ASV 2016 at Virginia Tech in Blacksburg, Virginia. You can find TWiV #395 at microbe.tv/twiv, or listen/view below. Click arrow to play Download TWiV 395 (44 MB .mp3, 60 min) Subscribe (free): iTunes, RSS, email, Google Play Music Become a patron of TWiV!
Sun, 26 Jun 2016 21:44:32 +0000
TWiV 394: Cards in a hand
Vincent and Alan speak with Erica Ollmann Saphire about her career and her work on understanding the functions of proteins of Ebolaviruses, Marburg virus, and other hemorrhagic fever viruses, at ASM Microbe 2016 in Boston, MA. You can find TWiV #394 at microbe.tv/twiv, or listen or watch the video below. Click arrow to play Download TWiV […]
Sun, 19 Jun 2016 10:28:48 +0000
When we decided to work on Zika virus in February 2016, experiments in mice were certainly part of our plans. However, one does not simply walk into a mouse facility and start inoculating animals with viruses! Carrying out animal experiments requires approval of a detailed protocol by the Institutional Animal Care and Use Committee (IACUC). I have filed […]
Thu, 16 Jun 2016 18:38:05 +0000
Are viruses alive?
In this new video from Virus Watch, I tackle the thorny question of whether viruses are alive. Plenty of people have offered their opinon on this question. The results of a poll I’ve had here on virology blog shows that people are divided on the answer. But I’m sure I have a good answer to […]
Thu, 16 Jun 2016 00:27:26 +0000
Interview with J. Michael Bishop
A major new feature of the fourth edition of Principles of Virology is the inclusion of 26 video interviews with leading scientists who have made significant contributions to the field of virology. For the chapter on Transformation and Oncogenesis, Vincent spoke with Nobel Laureate J. Michael Biship, of the University of California, San Francisco, about his career and his work on oncogenes.
Mon, 13 Jun 2016 15:16:28 +0000
TWiV 393: Lovers and livers
Possible sexual transmission of Zika virus, and a cell protein that allows hepatitis C virus replication in cell culture by enhancing vitamin E mediated protection against lipid peroxidation, are the subjects discussed by the TWiVerati on this week’s episode of the science show This Week in Virology. You can find TWiV #393 at microbe.tv/twiv, or listen […]
Sun, 12 Jun 2016 12:29:12 +0000
Zika virus and mosquito eradication
The Aedes aegypti eradication campaign coordinated by the Pan American Health Organization led by 1962 to elimination of this mosquito from 18 countries, including Brazil. Ae. aegypti transmits not only Zika virus, but dengue virus, chikungunya virus, and yellow fever virus. Could control measures be implemented today to achieve similar control of this mosquito? Two articles […]
Thu, 09 Jun 2016 21:23:50 +0000
Virus Watch: How mosquitoes spread viruses
In this episode of Virus Watch, I explain how mosquitoes spread viruses. We’ll look at how a mosquito finds a host, how it finds a blood vessel, and how it delivers viruses to a new host. Don’t blame mosquitoes for viral diseases: it’s not their fault!
Thu, 09 Jun 2016 13:43:14 +0000
Small Things Considered
A blog for sharing appreciation of the width and depth of microbes and microbial activities on this planet.
Microbe in Boston
by Elio | This year’s annual ASM meeting was different in that it combined the usual General Meeting with the antibiotic-oriented ICAAC meeting. The combined meeting was of course larger but, each of the two has always been gigantic, so bigger may not have been felt all that much. Anyhow, the cavernous spaces of the Boston Convention Center more than accommodated the hordes.
TWiM #130: Interkingdom interactions at ASM Microbe
See a special video version of This Week in Microbiology, recorded in front of a live audience at ASM Microbe 2016. The TWiMers get together at ASM Microbe 2016 in Boston to speak with David S. Schneider and Vanessa Sperandio to talk about their work on regulation of bacterial virulence in the gut by bacterial adrenergic sensors, and the physiological mechanisms that make us ill and that help us recover.
Retrospective - June 2016
by Elio | We continue our custom of listing the posts from the last half year, lightly annotated. Could retrospection lead to introspection?
Coughs, Coiled Coils, and the Classroom Cliché of Conformational Change
by Daniel P. Haeusser | So starts a verse in a modern version of the children’s folk song Pop Goes the Weasel. The 'whooping' sound generated through struggles for breath following fits of intense coughing characterizes pertussis. Caused by the beta-proteobacteria Bordetella pertussis, this highly contagious disease can seriously afflict humans of any age, particularly babies.
We are taking our customary two week vacation. Some of us will be traveling to Boston for Microbe 2016. If you'll also be there, make sure to attend the live recording of This Week in Microbiology and say hi to Elio!
To Retract or Not to Retract… That’s the Question
In the previous post I discussed  that editors of Science asked for the retraction of a paper linking XMRV retrovirus to ME/CFS. The decision of the editors was based on the failure of at least 10 other studies to confirm these findings and on growing support that the results were caused by contamination. When the authors refused […]
Tue, 07 Jun 2011 13:34:25 +0000
Science Asks to Retract the XMRV-CFS Paper, it Should Never Have Accepted in the First Place.
Wow! Breaking! As reported in WSJ earlier this week , editors of the journal Science asked Mikovits and her co-authors to voluntary retract their 2009 Science paper . In this paper Mikovits and colleagues of the Whittemore Peterson Institute (WPI) and the Cleveland Clinic, reported the presence of xenotropic murine leukemia virus–related virus (XMRV) in peripheral blood mononuclear cells […]
Thu, 02 Jun 2011 21:34:34 +0000
Does the NHI/FDA Paper Confirm XMRV in CFS? Well, Ditch the MR and Scratch the X… and… you’ve got MLV.
The long awaited paper that would ‘solve’ the controversies about the presence of Xenotropic Murine Leukemia Virus-related virus (XMRV) in patients with chronic fatigue syndrome (CFS) was finally published in PNAS last week . The study, a joint effort of the NIH and the FDA, was withheld, on request of the authors , because it contradicted […]
Mon, 30 Aug 2010 03:32:21 +0000