About viruses and viral disease
Sun, 17 Jun 2018 14:22:56 +0000
TWiV 498: Salivating at ASM Microbe
Vincent, Kathy and Rich travel to ASM Microbe 2018 in Atlanta where they speak with Stacy Horner and Ken Stapleford about their careers and their research. <span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”></span><span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”></span>&lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: […]
Sun, 17 Jun 2018 14:22:56 +0000
A Mouse Model System for Zika Virus Infection
By Gertrud U. Rey Zika virus (ZIKV) infection causes microcephaly in newborns and is causally associated with Guillian–Barré syndrome in adults. To date, there are no drugs available to prevent or treat ZIKV infection. ZIKV vaccine research is challenging because adult immunocompetent mice are resistant to ZIKV infection and disease. The primary immunologic response to […]
Fri, 15 Jun 2018 00:48:34 +0000
Trial By Error: A Curriculum for Treating CFS with CBT
By David Tuller, DrPH Ten years ago, the National Health Service began rolling out across England a program called Improving Access to Psychological Therapies, or IAPT. This program arose out of the notion that many people were suffering from untreated depression, anxiety and other psychiatric disorders. In parallel with that, research suggested that treating these […]
Thu, 14 Jun 2018 01:42:33 +0000
Trial By Error: More Letters About BMJ’s Flawed Pediatric Studies
By David Tuller, DrPH This morning I sent three more e-mails alerting interested parties to my concerns about two BMJ studies of children with ME/CFS. When it comes to research, kids are already a vulnerable population, and those with a stigmatizing illness even more so. That’s why it is both surprising and troubling that BMJ […]
Mon, 11 Jun 2018 15:05:35 +0000
TWiV 497: Europic 2018
At Europic 2018, a meeting on picornaviruses in the Netherlands, Vincent speaks with Sasha Gorbalenya, Jim Hogle, Ann Palmenberg and Frank van Kuppeveld about their careers and their research. <span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”></span><span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”></span>&lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; […]
Sun, 10 Jun 2018 11:26:17 +0000
Blocking rhinovirus infection by inhibiting a cell enzyme
The common cold is an infection of the upper respiratory tract that may be caused by many different viruses, but most frequently by rhinoviruses. A compound that inhibits a cell enzyme and blocks rhinovirus replication has the potential to be developed into an antiviral drug (link to paper). The common cold is an annoying but […]
Fri, 08 Jun 2018 01:28:14 +0000
Trial By Error: My Letter to the Science Media Centre about BMJ Study
By David Tuller, DrPH I have sent the following e-mail to Edward Sykes, the head of mental health and neuroscience at the Science Media Centre. The e-mail concerns the Lightning Process study published last year in Archives of Disease in Childhood. The SMC promoted the findings, which received widespread media coverage. I have cc’d Fiona […]
Wed, 06 Jun 2018 20:38:58 +0000
Trial By Error: A Letter to Health Officials About BMJ’s Lax Editorial Standards
By David Tuller, DrPH I am not sure what is going on at BMJ and why editors there seem incapable of acknowledging their flawed decision-making when it comes to two papers that should never have been accepted for publication. One violated BMJ’s policy that all trials must be properly prospectively registered, with no participants recruited […]
Wed, 06 Jun 2018 15:38:23 +0000
Trial By Error: My Letter to MP Monaghan About BMJ Studies
By David Tuller, DrPH I have been trying to convince editors at two BMJ journals to take responsibility for poor decisions. Despite serious nudging and prodding, I have been unsuccessful. The two papers I have criticized as being fraught with methodological and/or ethical missteps are these: “Clinical and cost-effectiveness of the Lightning Process in addition […]
Tue, 05 Jun 2018 14:28:02 +0000
Small Things Considered
A blog for sharing appreciation of the width and depth of microbes and microbial activities on this planet.
The Microbial Ecology of Chocolate
by Roberto | Being retired, I no longer get the opportunity to brainstorm with post-doctoral candidates hoping to join the lab about possible projects to pursue (an activity that I greatly enjoyed for many years). But ideas of interesting research areas in the microbial sciences still arise often in my mind. So I will, on occasion, use...
Retrospective, June 2018
by Elio | As is our custom, we provide a lightly annotated list of our posts from the past half year.
On Bacteria Getting Fat
by Roberto | In bacteria and archaea, lipids seem to be found mainly in the cell membrane. Can you think of possible functions for lipids elsewhere in bacterial and/or archaeal cells? On first inspection, these two opening sentences have the makings of an STC Talmudic Question. Except for the fact that intracellular fat accumulation or, more precisely, cytoplasmic lipidic inclusions...
No hiding among the trees: forensic phylogenetics
by Jamie Henzy | Some 50 years ago, Emile Zuckerkandl and Linus Pauling proposed that molecules could be read as "documents of evolutionary history". The molecules to which they referred were proteins, and the sequence of the amino acids that specified each.
Talmudic Question #154
Mycorrhizal fungi are known to carry out many activities beneficial to plants, such as transporting water and nutrients, protecting against pathogens, and permitting communication between plants. Do they also carry pathogens such as viruses or bacteria? If no, why not?
To Retract or Not to Retract… That’s the Question
In the previous post I discussed  that editors of Science asked for the retraction of a paper linking XMRV retrovirus to ME/CFS. The decision of the editors was based on the failure of at least 10 other studies to confirm these findings and on growing support that the results were caused by contamination. When the authors refused […]
Tue, 07 Jun 2011 13:34:25 +0000
Science Asks to Retract the XMRV-CFS Paper, it Should Never Have Accepted in the First Place.
Wow! Breaking! As reported in WSJ earlier this week , editors of the journal Science asked Mikovits and her co-authors to voluntary retract their 2009 Science paper . In this paper Mikovits and colleagues of the Whittemore Peterson Institute (WPI) and the Cleveland Clinic, reported the presence of xenotropic murine leukemia virus–related virus (XMRV) in peripheral blood mononuclear cells […]
Thu, 02 Jun 2011 21:34:34 +0000
Does the NHI/FDA Paper Confirm XMRV in CFS? Well, Ditch the MR and Scratch the X… and… you’ve got MLV.
The long awaited paper that would ‘solve’ the controversies about the presence of Xenotropic Murine Leukemia Virus-related virus (XMRV) in patients with chronic fatigue syndrome (CFS) was finally published in PNAS last week . The study, a joint effort of the NIH and the FDA, was withheld, on request of the authors , because it contradicted […]
Mon, 30 Aug 2010 03:32:21 +0000