About viruses and viral disease
Mon, 23 Oct 2017 16:11:24 +0000
Trial By Error: Current NICE Guidance Stands, For Now
By David Tuller, DrPH Last week I sent an e-mail with some questions to Sir Andrew Dillon, the chief executive of the National Institute for Health and Care Excellence (NICE). In particular, the questions involved the status of the ten-year-old guidance for CFS/ME, CG53, and of references to the illness elsewhere within the NICE system. […]
Mon, 23 Oct 2017 16:11:24 +0000
TWiV 464: Boston baked viruses
At Tufts University Dental School in Boston, Vincent speaks with Katya Heldwein and Sean Whelan about their careers and their work on herpesvirus structure and replication of vesicular stomatitis virus. Click arrow to play Download TWiV 464 (53 MB .mp3, 88 min) Subscribe (free): iTunes, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv
Sun, 22 Oct 2017 13:19:30 +0000
From cell proteins to viral capsids
We have previously discussed the idea that viruses originated from selfish genetic elements such as plasmids and transposons when these nucleic acids acquired structural proteins (see A plasmid on the road to becoming a virus). I want to explore in more detail the idea that the structural proteins of viruses likely originated from cell proteins (link to […]
Fri, 20 Oct 2017 02:54:10 +0000
Trial By Error: Another Letter to NICE’s Sir Andrew Dillon
By David Tuller, DrPH First, for those who might have missed it, here’s a conversation from This Week in Virology (TWiV), posted a few days ago. Dr. Racaniello and I discuss the CDC, NICE, Esther Crawley’s ethically challenged behavior, the CMRC, and other stuff. Second, earlier today, I sent the following e-mail to Sir Andrew […]
Tue, 17 Oct 2017 18:09:59 +0000
Truth Wins: A Practical Guide to Succeeding in Biomedical Research, by Jonathan Yewdell
Jonathan Yewdell, Chief of the Cellular Biology Section at the National Institute of Allergy and Infectious Diseases, has written a book entitled Truth Wins: A Practical Guide to Succeeding in Biomedical Research. Dr. Yewdell is well known for his presentations about the problems with biomedical science, a subject we discussed on TWiV 208: The Biomedical […]
Mon, 16 Oct 2017 16:30:22 +0000
TWiV 463: We haven’t meth but these names ring Nobel
The TWiViridae review the 2017 Nobel Prizes for cryoEM and circadian rhythms, and discuss modulation of plant virus replication by RNA methylation. Click arrow to play Download TWiV 463 (63 MB .mp3, 104 min) Subscribe (free): iTunes, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv
Sun, 15 Oct 2017 15:20:15 +0000
Have a methyl with your viral RNA
Chemical modification of RNA by the addition of methyl groups is known to alter gene expression without changing the nucleotide sequence. The addition of a methyl group to adenosine has been found to regulate gene expression of animal viruses, and most recently of plant viruses. The illustration shows a methyl (CH3-) group added to the […]
Fri, 13 Oct 2017 01:54:35 +0000
TWiV 462: Splicing RNA with Phillip A. Sharp
Vincent speaks with 1993 Nobel Laureate Phillip A. Sharp about his career and his seminal discovery of RNA splicing in mammalian cells, which changed our understanding of gene structure. Click arrow to play Download TWiV 462 (24 MB .mp3, 39 min) Subscribe (free): iTunes, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv
Tue, 10 Oct 2017 16:06:16 +0000
Trial By Error: NIH Grants $2.1 Million to UK Biobank!
By David Tuller, DrPH The National Institutes of Health is making a $2.1 million grant to the UK ME/CFS Biobank–a huge endorsement of this important project run by CureME and housed at the London School of Hygiene and Tropical Medicine. Here’s what the ME Association wrote on its website: “The funding represents the biggest ever […]
Wed, 04 Oct 2017 00:16:03 +0000
Small Things Considered
A blog for sharing appreciation of the width and depth of microbes and microbial activities on this planet.
The Human Circadian Rhythm is a Microbial Business
by Elio | Nice of the Nobel Committee to award the 2017 prize for Medicine for work on the circadian rhythm of fruit flies. This gives us an entry into a paper that helps explain how this cycle actually works. It won't surprise readers of this blog that the answer is microbial and concerns, not unexpectedly, the intestinal microbiota
"We Are What We Are"
by Christoph Weigel | If I were a stage director and contracted for another revival of the Broadway show 'La Cage aux Folles' (including the chorus line's "We Are What We Are") I would not waver a minute to choose for all leading roles members of the Pseudomonas family. All are true professionals (method acting, Meisner technique), versatile in acting solo, or as a team, in dancing and in singing.
Why Be Intracellular and Be Motile?
by Elio | Why would a strict intracellular organism be motile? In the case of rickettsiae (and some not strict intracellular parasites such as the listeriae and shigellae), motility is carried out through the activity of the host's actin, apparently for the purpose of infecting adjacent cells. I am not talking about that, but rather I will consider here...
Plimpton v. Muybridge
by Christoph Weigel | In July, an article by journalist Megan Molteni from the tech magazine Wired had hit the headlines: "Scientists Upload a Galloping Horse GIF Into Bacteria With Crispr". Wow! And a second 'wow!' followed suit when a few weeks later an article by journalist Maev Kennedy in the British newspaper The Guardian boasted the title "Mathematical secrets......
Scientific Publishing – A Conversation
by George O'Toole and Roberto | Publishing the results of research in journals remains the most important lasting record of scientific work. Yet, if you ask almost any scientist about the process of publishing itself they will likely bemoan the current situation. Perhaps this has always been the case, it's true that people tend to long for "the good old days." But perhaps...
To Retract or Not to Retract… That’s the Question
In the previous post I discussed  that editors of Science asked for the retraction of a paper linking XMRV retrovirus to ME/CFS. The decision of the editors was based on the failure of at least 10 other studies to confirm these findings and on growing support that the results were caused by contamination. When the authors refused […]
Tue, 07 Jun 2011 13:34:25 +0000
Science Asks to Retract the XMRV-CFS Paper, it Should Never Have Accepted in the First Place.
Wow! Breaking! As reported in WSJ earlier this week , editors of the journal Science asked Mikovits and her co-authors to voluntary retract their 2009 Science paper . In this paper Mikovits and colleagues of the Whittemore Peterson Institute (WPI) and the Cleveland Clinic, reported the presence of xenotropic murine leukemia virus–related virus (XMRV) in peripheral blood mononuclear cells […]
Thu, 02 Jun 2011 21:34:34 +0000
Does the NHI/FDA Paper Confirm XMRV in CFS? Well, Ditch the MR and Scratch the X… and… you’ve got MLV.
The long awaited paper that would ‘solve’ the controversies about the presence of Xenotropic Murine Leukemia Virus-related virus (XMRV) in patients with chronic fatigue syndrome (CFS) was finally published in PNAS last week . The study, a joint effort of the NIH and the FDA, was withheld, on request of the authors , because it contradicted […]
Mon, 30 Aug 2010 03:32:21 +0000