About viruses and viral disease
Fri, 18 Aug 2017 02:03:25 +0000
Purging the PERVs
There aren’t enough human organs to meet the needs for transplantation, so we have turned to pigs. Unfortunately pig cells contain porcine endogenous retroviruses, PERVS, which could infect the transplant recipient, leading to tumor formation. But why worry? Just use CRISPR to purge the PERVs. The genomes of many species on Earth are littered with endogenous […]
Fri, 18 Aug 2017 02:03:25 +0000
Trial by Error: My E-Mail Exchange With NICE Chief Executive
By David Tuller, DrPH On Friday, I had an e-mail exchange with Sir Andrew Dillon, chief executive of the NICE Guidance Executive. The other seven Guidance Executive members are various directors within the NICE hierarchy, including the communications director. This group will make the final decision about whether to accept the provisional decision of a […]
Mon, 14 Aug 2017 16:06:25 +0000
TWiV 454: FGCU, Zika
Sharon Isern and Scott Michael return to TWiV for a Zika virus update, including their work on viral evolution and spread, and whether pre-existing immunity to dengue virus enhances pathogenesis. Click arrow to play Download TWiV 454 (65 MB .mp3, 108 min) Subscribe (free): iTunes, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv
Sun, 13 Aug 2017 15:03:28 +0000
Does prior dengue virus infection exacerbate Zika virus disease?
The short answer to the question posed in the title of this blog is: we don’t know. Why would we even consider that a prior dengue virus infection would increase the severity of a Zika virus infection? The first time you are infected with dengue virus, you are likely to have a mild disease involving […]
Fri, 11 Aug 2017 01:50:16 +0000
Trial by Error: Retired PACE Investigator Peter White and Swiss Re
By David Tuller, DrPH On November 17, 2015, a few weeks after publication of my 15,000-word investigation of the PACE trial, I posted a blog about a talk Peter White gave to Swiss Re employees on the findings from his bogus study. Professor White, of course, was the lead PACE investigator and also served–and apparently […]
Mon, 07 Aug 2017 15:59:44 +0000
TWiV 453: Neurovirology with Diane Griffin
From the Vector-Borne Viruses Symposium in Hamilton, Montana, Dickson and Vincent speak with Diane Griffin about her career and her work on understanding viral infections of the central nervous system. Click arrow to play Download TWiV 453 (39 MB .mp3, 64 min) Subscribe (free): iTunes, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv
Sun, 06 Aug 2017 13:16:45 +0000
Trial by Error: The Science Media Centre’s Desperate Efforts to Defend PACE
By David Tuller, DrPH This week, the Journal of Health Psychology published a special issue containing a raft of commentaries on the PACE trial. Most of them slammed the study for its many, many unacceptable flaws. Not surprisingly, Sir Simon Wessely’s lackeys at the Science Media Centre immediately posted three comments from “experts” lauding the […]
Wed, 02 Aug 2017 16:28:02 +0000
Trial by Error: NICE Rejects My FOI Request
By David Tuller, DrPH The National Institute for Health and Care Excellence, the U.K. organization that develops clinical guidelines for medical conditions, has rejected my freedom-of-information request for the names of the experts involved in the reassessment of the guidance for the illness it calls CFS/ME. This isn’t surprising, since the agency also recently rejected […]
Mon, 31 Jul 2017 13:32:29 +0000
TWiV 452: Kiss that frog
Lynda Coughlan joins the weekly virtual bus companions for a discussion of a host defense peptide from frogs that destroys influenza virus, and mouse models for acute and chronic hepacivirus infection. Click arrow to play Download TWiV 452 (68 MB .mp3, 113 min) Subscribe (free): iTunes, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv
Sun, 30 Jul 2017 11:23:38 +0000
Small Things Considered
A blog for sharing appreciation of the width and depth of microbes and microbial activities on this planet.
Thinking About Science
by Roberto | One of the features I most treasure of the nearly fifty years I have been involved in science has been the capacity to take time and simply think. Call it a privilege, call it a luxury; I call it a necessity.
TWiM #158: The bottom line
Prokaryotic viral DNA in mammalian brain, and how diarrhea is beneficial, by clearing enteric pathogens.
A Fascination with Caves
by Elio | Caves captivate everybody. They are totally unlike our usual landscape, bewildering and challenging in design. No wonder that they attract casual visitors and explorers alike. Among the latter, we count speleomicrobiologists who search such secluded environments for unusual microbiota. The subject is well developed and even the topic of specialized meetings. But do not think that a cave is just a cave...
by Christoph Weigel | You may wonder why you read the same motto twice in a week in STC but there's a reason. I will follow up Merry's recent post, her lucid description of in silico and in vivo experiments demonstrating that evolution can achieve complexity by small incremental steps if they confer...
by Merry Youle | Evolution skeptics point to complex biological features as evidence that the amazing intricacy of the biological world could not be the product of blind mutation. The de novo creation of such complexity, they argue, would require far too many coordinated mutational changes before the new form provided any fitness benefit. Thus, evolution simply cannot explain such apparent leaps. Evolutionists, beginning with Darwin, and continuing today, have posited that...
To Retract or Not to Retract… That’s the Question
In the previous post I discussed  that editors of Science asked for the retraction of a paper linking XMRV retrovirus to ME/CFS. The decision of the editors was based on the failure of at least 10 other studies to confirm these findings and on growing support that the results were caused by contamination. When the authors refused […]
Tue, 07 Jun 2011 13:34:25 +0000
Science Asks to Retract the XMRV-CFS Paper, it Should Never Have Accepted in the First Place.
Wow! Breaking! As reported in WSJ earlier this week , editors of the journal Science asked Mikovits and her co-authors to voluntary retract their 2009 Science paper . In this paper Mikovits and colleagues of the Whittemore Peterson Institute (WPI) and the Cleveland Clinic, reported the presence of xenotropic murine leukemia virus–related virus (XMRV) in peripheral blood mononuclear cells […]
Thu, 02 Jun 2011 21:34:34 +0000
Does the NHI/FDA Paper Confirm XMRV in CFS? Well, Ditch the MR and Scratch the X… and… you’ve got MLV.
The long awaited paper that would ‘solve’ the controversies about the presence of Xenotropic Murine Leukemia Virus-related virus (XMRV) in patients with chronic fatigue syndrome (CFS) was finally published in PNAS last week . The study, a joint effort of the NIH and the FDA, was withheld, on request of the authors , because it contradicted […]
Mon, 30 Aug 2010 03:32:21 +0000