About viruses and viral disease
Wed, 17 Oct 2018 09:41:40 +0000
Trial By Error: The Psychosomatic Conference’s Pathetic Response
By David Tuller, DrPH After I posted yesterday’s blog about Per Fink’s upcoming appearance at the fourth annual Columbia Psychosomatic Conference being held this weekend, I received the following e-mail from Columbia’s Alla Landa. She is an assistant professor of “clinical psychology in psychiatry”–whatever that means–and director of the conference. I found her note unsatisfactory […]
Wed, 17 Oct 2018 09:41:40 +0000
Trial By Error: Per Fink in New York
By David Tuller, DrPH Someone uninformed or stupid or maybe both decided to invite Danish physician Per Fink to present at a conference on so-called psychosomatic medicine being held this weekend at Columbia University. Fink—I won’t dignify him by using an honorific–is a scary guy. He should never have been provided with this prestigious platform—in […]
Tue, 16 Oct 2018 21:14:48 +0000
TWiV 515: When virus is in retrograde
The TWiV team notes the passing of Tom Steitz, an outbreak of acute flaccid myelitis in the US, a continuing Ebola virus outbreak in DRC, respiratory vaccinia due to inhalation of ground up rabbit skin, and how a human papillomavirus capsid protein directs virus-containing endosomes towards the nucleus. <span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: […]
Sun, 14 Oct 2018 21:48:38 +0000
A Hippocratic oath for scientists
At the First Annual Lab Coat Ceremony for Ph.D. and MD/Ph.D. students at Icahn School of Medicine at Mount Sinai, at which I delivered the Keynote Address, the students and their mentors were asked to recite oaths pledging their dedication to the field. Such oaths have been called ‘Hippocratic oaths for Scientists’, similar to the […]
Thu, 11 Oct 2018 15:35:10 +0000
Influenza vaccine is safe for those with egg allergies
With the influenza season approaching in the northern hemisphere, vaccination is a means of preventing infection. If you have egg allergies, you no longer have to worry about receiving influenza vaccine. Because most influenza vaccines are grown in embryonated chicken eggs, and may contain residual egg protein, their use in individuals with egg allergy has […]
Wed, 10 Oct 2018 20:32:26 +0000
Trial By Error: My First Post on the IAPT Program
By David Tuller, DrPH Since 2008, the English arm of the National Health Service has been rolling out a program called Improving Access to Psychological Therapies, or IAPT. More than 900,000 people now receive IAPT services annually. This program arose out of the notion that many people were suffering from untreated depression, anxiety and other psychiatric […]
Wed, 10 Oct 2018 10:30:00 +0000
Trial By Error: My Latest Letter to Archives of Disease in Childhood
By David Tuller, DrPH I sent the following e-mail today to Dr Nick Brown, the editor-in-chief of Archives of Disease in Childhood, the journal that published the Lightning Process study a year ago. I cc’d Dr Fiona Godlee, editorial director of BMJ, which publishes Archives. ********** Dear Dr Brown— As you know, I have been […]
Mon, 08 Oct 2018 17:58:53 +0000
TWiV 514: Staying below the ADAR
The TWiVumvirate reviews this years crop of Nobel Prizes, and how cells prevent leakage of mitochondrial double-stranded RNA into the cytoplasm, which would otherwise lead to the production of interferon. <span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”></span><span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”></span>&lt;span data-mce-type=”bookmark” style=”display: inline-block; width: […]
Sun, 07 Oct 2018 13:15:06 +0000
Mitochondrial double-stranded RNA is dangerous
Mitochondria are descended from bacteria that invaded cells 1.5 billion years ago and never left. The mitochondrial genome is like that of bacteria: circular double-stranded DNA, only smaller. And just like the genome of bacteria, RNA can be made from both strands of mitochondrial DNA – which results in the formation of dsRNA. Fortunately there […]
Thu, 04 Oct 2018 05:20:38 +0000
Small Things Considered
A blog for sharing appreciation of the width and depth of microbes and microbial activities on this planet.
Shining a light on Vibrio DNA uptake
by Rachel Diner | Vibriocholerae is "kind of a big deal" in the bacterial world and a popular topic here on STC. Beyond being the causative agent for the disease cholera, it's a model bacterium for studying horizontal gene transfer and interbacterial competition. A recent study in Nature Microbiology sheds new light (literally) on how this happens.
Vaccines and the Fight Against Antibiotic Resistance
by Roberto | For the vast majority of the natural history of Homo sapiens, some 200,000 years, the average life expectancy at birth has been around 30 years. What I find most amazing is that as recently as 1900 the world average human life expectancy at birth had remained unchanged.
On your marks, get set, go!
by Christoph | When did you first hear about the "genetic code"? In high school? Or in college, in an undergraduate course in molecular biology and/or genetics? In either case you were certainly shown the famous codon table that specifies which of the 64 possible triplets in messenger RNA (mRNA) are translated into one of the 20 canonical...
Mono Lake (a Snippet)
by Elio | Travel down the eastern slope of California's Sierra Nevada and you will run into a number of breathtaking sights. Ranking high among them is Mono Lake, a large shallow lake that sports a collection of strange limestone columns. Protruding some 30 feet above the water surface, these structures, known as chimneys, consist of calcium carbonate...
How Bacteria on our Skin Might Prevent Skin Cancer
by Jammal Abu-khazneh and Chih-Kai Yang | The skin is the largest organ in the human body and is home to diverse microbial communities. While this may be unsettling for some germophobes, recent work has uncovered potential health benefits from bacteria that are part of our normal skin microbiomes.
To Retract or Not to Retract… That’s the Question
In the previous post I discussed  that editors of Science asked for the retraction of a paper linking XMRV retrovirus to ME/CFS. The decision of the editors was based on the failure of at least 10 other studies to confirm these findings and on growing support that the results were caused by contamination. When the authors refused […]
Tue, 07 Jun 2011 13:34:25 +0000
Science Asks to Retract the XMRV-CFS Paper, it Should Never Have Accepted in the First Place.
Wow! Breaking! As reported in WSJ earlier this week , editors of the journal Science asked Mikovits and her co-authors to voluntary retract their 2009 Science paper . In this paper Mikovits and colleagues of the Whittemore Peterson Institute (WPI) and the Cleveland Clinic, reported the presence of xenotropic murine leukemia virus–related virus (XMRV) in peripheral blood mononuclear cells […]
Thu, 02 Jun 2011 21:34:34 +0000
Does the NHI/FDA Paper Confirm XMRV in CFS? Well, Ditch the MR and Scratch the X… and… you’ve got MLV.
The long awaited paper that would ‘solve’ the controversies about the presence of Xenotropic Murine Leukemia Virus-related virus (XMRV) in patients with chronic fatigue syndrome (CFS) was finally published in PNAS last week . The study, a joint effort of the NIH and the FDA, was withheld, on request of the authors , because it contradicted […]
Mon, 30 Aug 2010 03:32:21 +0000