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Table of Contents for this page:

  • Current Issue
  • Advanced Online Publications Articles

  • Current Issue of Nature Structural and Molecular Biology

    Nature Structural aamp; Molecular Biology - Issue - nature.com science feeds

  • A molecular arms race: new insights into anti-CRISPR mechanisms

  • Bacteria and phages are engaged in a molecular arms race, constantly coevolving to best each other. The crystal structure of the anti-CRISPR protein AcrF3 bound to Cas3, an essential component of CRISPR-based immunity, sheds light on how phages have found ways to suppress bacterial immunity.

  • Hsp70 chaperones use ATP to remodel native protein oligomers and stable aggregates by entropic pulling

  • Forceful unfolding by entropic pulling is the general mechanism by which Hsp70 and Hsp110 chaperones control the oligomeric states, structures and activities of cellular proteins.

  • Sending protein aggregates into a downward spiral

  • Cells deploy the Hsp100 family of ATP-dependent machines to work with cellular chaperones in dismantling dangerous protein aggregates. New studies reveal an unprecedented spiral structure that provides mechanistic insight into the protein disaggregase Hsp104.

  • The pol II CTD: new twists in the tail

  • In this Review, the authors discuss recent advances in understanding how post-translational modifications of the RNA polymerase II C-terminal domain (CTD) regulate transcription and RNA processing events and control gene expression.

  • An atomic structure of the human 26S proteasome

  • A cryo-EM structure of the human 26S proteasome in a resting state at an average resolution of 3.5Å reveals details in the interactions between subunits. An additional structure of the proteasome with USP14 bound suggests a mechanism for its activation.

  • Skp is a multivalent chaperone of outer-membrane proteins

  • Mass spectrometry, kinetics studies and in silico analyses indicate that multiple copies of the Skp chaperone are required for sequestration of 16-stranded or larger OMPs and prevention of their aggregation.

  • Structural basis for tRNA modification by Elp3 from Dehalococcoides mccartyi

  • The eukaryotic Elongator complex participates in modification of uridines in tRNAs. Structural and functional work on a bacterial Elp3, the catalytic subunit of Elongator, provides insight into the function and mechanism of this important enzyme.

  • m1A and m1G disrupt A-RNA structure through the intrinsic instability of Hoogsteen base pairs

  • The inability of A-form RNA to form Hoogsteen base pairs provides a mechanism for how post-transcriptional modifications can disrupt RNA structure and might help explain why DNA is the molecular choice for storing genetic information.

  • Iterative structure-based improvement of a fusion-glycoprotein vaccine against RSV

  • An interactive structure-based approach was used to improve a vaccine antigen against respiratory syncytium virus (RSV), thus leading to immunogens with higher stability that elicit higher neutralizing titers in mice.

  • Clathrin-coat disassembly illuminates the mechanisms of Hsp70 force generation

  • Light-scattering kinetics and atomic force and electron microscopy analyses show that Hsp70-mediated disassembly of clathrin cages occurs via a collision-pressure mechanism consistent with the entropic pulling model.

  • Spiral architecture of the Hsp104 disaggregase reveals the basis for polypeptide translocation

  • A cryo-EM structure of yeast AAA+ protein disaggregase Hsp104 with AMP-PNP reveals a spiral arrangement of the protomers and a continuous path for polypeptide translocation that explains Hsp104's processivity mechanism during disaggregation.

  • One-way membrane trafficking of SOS in receptor-triggered Ras activation

  • Analyses in supported lipid bilayers and in cells shed light on the roles of multiple SOS-membrane interactions in SOS's membrane recruitment and association, processive activation of Ras and signal attenuation.

  • Structure of a pathogen effector reveals the enzymatic mechanism of a novel acetyltransferase family

  • Structural and functional analyses of HopZ1a, a member of the YopJ family of bacterial type III–secreted effectors, reveal the structural basis of YopJ effectors’ noncanonical acetyltransferase activity and allosteric regulation by inositol hexakisphosphate.

  • Cryomicroscopy provides structural snapshots of influenza virus membrane fusion

  • Cryo-EM and tomography imaging of influenza virus fusion with target membranes reveal structural intermediates of HA surface glycoprotein and their interactions with membranes as well as ultrastructural changes in the virus that accompany membrane fusion.

  • An accurately preorganized IRES RNA structure enables eIF4G capture for initiation of viral translation

  • The solution structure of the J-K region of the EMCV IRES establishes a preorganized recognition mode for hijacking translation initiation factor 4G.

  • Extended surface for membrane association in Zika virus NS1 structure

  • The crystal structure of full-length NS1 protein from Zika virus reveals an extended surface for membrane association and a highly variable polar surface.

  • Structural basis of Cas3 inhibition by the bacteriophage protein AcrF3

  • The crystal structure of the phage anti-CRISPR protein AcrF3 in complex with Cas3 reveals its mode of inhibition of the CRISPR–Cas bacterial immune system.

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    Nature -Advance Online Publications

    Return To Top of the Page

    Nature Structural aamp; Molecular Biology - AOP - nature.com science feeds

  • An accurately preorganized IRES RNA structure enables eIF4G capture for initiation of viral translation

  • The solution structure of the J-K region of the EMCV IRES establishes a preorganized recognition mode for hijacking translation initiation factor 4G.

  • Structure of a pathogen effector reveals the enzymatic mechanism of a novel acetyltransferase family

  • Structural and functional analyses of HopZ1a, a member of the YopJ family of bacterial type III–secreted effectors, reveal the structural basis of YopJ effectors’ noncanonical acetyltransferase activity and allosteric regulation by inositol hexakisphosphate.

  • Cryomicroscopy provides structural snapshots of influenza virus membrane fusion

  • Cryo-EM and tomography imaging of influenza virus fusion with target membranes reveal structural intermediates of HA surface glycoprotein and their interactions with membranes as well as ultrastructural changes in the virus that accompany membrane fusion.

  • One-way membrane trafficking of SOS in receptor-triggered Ras activation

  • Analyses in supported lipid bilayers and in cells shed light on the roles of multiple SOS-membrane interactions in SOS's membrane recruitment and association, processive activation of Ras and signal attenuation.

  • Iterative structure-based improvement of a fusion-glycoprotein vaccine against RSV

  • An interactive structure-based approach was used to improve a vaccine antigen against respiratory syncytium virus (RSV), thus leading to immunogens with higher stability that elicit higher neutralizing titers in mice.

  • Clathrin-coat disassembly illuminates the mechanisms of Hsp70 force generation

  • Light-scattering kinetics and atomic force and electron microscopy analyses show that Hsp70-mediated disassembly of clathrin cages occurs via a collision-pressure mechanism consistent with the entropic pulling model.

  • Spiral architecture of the Hsp104 disaggregase reveals the basis for polypeptide translocation

  • A cryo-EM structure of yeast AAA+ protein disaggregase Hsp104 with AMP-PNP reveals a spiral arrangement of the protomers and a continuous path for polypeptide translocation that explains Hsp104's processivity mechanism during disaggregation.

  • m1A and m1G disrupt A-RNA structure through the intrinsic instability of Hoogsteen base pairs

  • The inability of A-form RNA to form Hoogsteen base pairs provides a mechanism for how post-transcriptional modifications can disrupt RNA structure and might help explain why DNA is the molecular choice for storing genetic information.

  • Structural basis for tRNA modification by Elp3 from Dehalococcoides mccartyi

  • The eukaryotic Elongator complex participates in modification of uridines in tRNAs. Structural and functional work on a bacterial Elp3, the catalytic subunit of Elongator, provides insight into the function and mechanism of this important enzyme.

  • Skp is a multivalent chaperone of outer-membrane proteins

  • Mass spectrometry, kinetics studies and in silico analyses indicate that multiple copies of the Skp chaperone are required for sequestration of 16-stranded or larger OMPs and prevention of their aggregation.

  • An atomic structure of the human 26S proteasome

  • A cryo-EM structure of the human 26S proteasome in a resting state at an average resolution of 3.5Å reveals details in the interactions between subunits. An additional structure of the proteasome with USP14 bound suggests a mechanism for its activation.

  • Extended surface for membrane association in Zika virus NS1 structure

  • The crystal structure of full-length NS1 protein from Zika virus reveals an extended surface for membrane association and a highly variable polar surface.

  • Structural basis of Cas3 inhibition by the bacteriophage protein AcrF3

  • The crystal structure of the phage anti-CRISPR protein AcrF3 in complex with Cas3 reveals its mode of inhibition of the CRISPR–Cas bacterial immune system.
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