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Table of Contents for this page:

  • Current Issue
  • Advanced Online Publications Articles

  • Current Issue of Nature Structural and Molecular Biology

    Nature Structural aamp; Molecular Biology - Issue - science feeds

  • NMR Exchange Format: a unified and open standard for representation of NMR restraint data

  • Grab the wiggly tail: new insights into the dynamics of circadian clocks

  • How do molecular interactions determine the period length of a circadian oscillator? In mammals, a disordered region of the BMAL1 transcription factor that is able to interact with activators or repressors seems to perform this function.

  • Exposing the secrets of sex determination

  • Sex-determining transcription factors recognize their genomic target sites through mechanisms of DNA base-and-shape readout in combination with cooperative binding. Murphy et al. reveal that for one such transcription factor, DMRT1, the DNA sequence-and-shape features of its binding sites determine whether it binds DNA as a dimer, trimer or tetramer; they also characterize protein-DNA contacts that affect gender phenotypes in flies and humans.

  • RGM co-receptors add complexity to BMP signaling

  • Ten years ago, the repulsive guidance molecules (RGMs), a family of three glycosylphosphatidylinositol–anchored glycoproteins, were identified as highly specific co-receptors of the bone morphogenetic proteins (BMPs). Newly reported crystal structures provide exciting insights into how RGM co-receptors may modulate BMP signaling.

  • A-form DNA for survival

  • An unexpected role for mitochondrial ClpX

  • The ghost in the machine

  • An ancient protein-DNA interaction underlying metazoan sex determination

  • DMRT transcription factors, key regulators of metazoan sexual development, use a unique DNA binding mode critical for male-to-female sex reversal in humans.

  • A dynamic DNA-repair complex observed by correlative single-molecule nanomanipulation and fluorescence

  • Single-molecule imaging reveals how stalled Escherichia coli RNA polymerase is displaced by the superfamily 2 DNA translocase (SF2) repair factor Mfd to permit transcription-coupled DNA repair.

  • Repulsive guidance molecule is a structural bridge between neogenin and bone morphogenetic protein

  • Structural and functional analyses reveal how human repulsive-guidance-molecule glycoproteins activate bone morphogenic protein (BMP) signaling and physically link the latter to the neogenin pathway.

  • The mechanism of inhibition of protein synthesis by the proline-rich peptide oncocin

  • The crystal structure of the thermophilic 70S ribosome bound to the antimicrobial peptide Onc112 reveals that the peptide interacts with three adjacent functional sites in the ribosome.

  • The proline-rich antimicrobial peptide Onc112 inhibits translation by blocking and destabilizing the initiation complex

  • Structural and biochemical studies reveal how the antimicrobial peptide Onc112 binds to bacterial ribosomes and show that Onc112 blocks and destabilizes the translation-initiation complex.

  • Cryptochrome 1 regulates the circadian clock through dynamic interactions with the BMAL1 C terminus

  • The mammalian circadian cycle is determined by sequential activation of clock target-gene expression by CLOCK–BMAL and subsequent repression by CRY. Biochemical and NMR data now show that Cry1 competes with coactivators for binding to the BMAL1 transcriptional-activation domain to regulate circadian cycling.

  • Structure of the Vif-binding domain of the antiviral enzyme APOBEC3G

  • Evolution- and structure-guided mutagenesis allows elucidation of the solution NMR structure of the N-terminal domain of APOBEC3G. Mapping of HIV-1 Vif binding to the APOBEC3G NTD reveals an interaction interface distinct from those in other APOBEC3 proteins.

  • Vps4 disassembles an ESCRT-III filament by global unfolding and processive translocation

  • HDX-MS and cross-linking analyses by Hurley and colleagues reveal that the AAA+ ATPase Vps4 disassembles a substrate by global unfolding and translocation through its central pore, in a mechanism reminiscent of that of the unfoldase ClpX.

  • Aβ(1–42) fibril structure illuminates self-recognition and replication of amyloid in Alzheimer's disease

  • Aβ(1–42) is the most pathogenic amyloid-β species in Alzheimer's disease (AD). The solid-state NMR–based atomic model of an Aβ(1–42) fibril elucidates the mechanism of fibril formation and propagation in AD and other amyloid diseases.

  • X-ray structures of Drosophila dopamine transporter in complex with nisoxetine and reboxetine

  • Crystal structures of the Drosophila melanogaster dopamine transporter dDAT in complex with inhibitors reboxetine and nisoxetine shed light on the molecular basis of antidepressant selectivity and specificity.

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    Nature -Advance Online Publications

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    Nature Structural aamp; Molecular Biology - AOP - science feeds

  • Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env

  • The structure of the ligand-free HIV-1–Env trimer allows conformational fixation of Env and generation of an antigen that binds CD4 with high affinity and is recognized by broadly neutralizing antibodies but not poorly neutralizing ones.

  • Small-RNA asymmetry is directly driven by mammalian Argonautes

  • Asymmetric selection of single-stranded guide RNAs from double-stranded RNA precursors is determined by Ago2, which detects 5′-nucleotide identity and thermodynamic stability of microRNA duplex ends via its MID domain.

  • Crystal structure of human stearoyl–coenzyme A desaturase in complex with substrate

  • The crystal structure of human stearoyl-CoA desaturase-1 in complex with its natural substrate provides a close-up view of a key enzymatic step in the synthesis of unsaturated fatty acids.

  • The Anopheles-midgut APN1 structure reveals a new malaria transmission–blocking vaccine epitope

  • New X-ray crystal structure and immunoanalyses of alanyl aminopeptidase N (AnAPN1), a gut antigen of the Anopheles mosquito vector of Plasmodium falciparum, reveal how AnAPN1-specific antibodies block transmission of the malarial parasite.

  • ATP binding drives substrate capture in an ECF transporter by a release-and-catch mechanism

  • Bacterial energy-coupling factor (ECF) transporters mediate ATP-dependent uptake of essential environmental micronutrients. Biochemical and fluorescence analyses now show that ATP binding promotes release of a substrate-capturing subunit that dynamically reassociates with the transmembrane module during the transport cycle.

  • The pilus usher controls protein interactions via domain masking and is functional as an oligomer

  • Biochemical analyses show that in the Escherichia coli type I pilus the plug domain controls activation of usher by masking the substrate-binding site in the C-terminal domains when usher is in resting state.

  • Dynamic binding mode of a Synaptotagmin-1–SNARE complex in solution

  • The NMR-derived structural model of the dynamic interaction between synaptotagmin-1 and the SNARE complex contributes to addressing the longstanding problem of how synaptotagmin-1 triggers neurotransmitter release.

  • Structure of the Atg101–Atg13 complex reveals essential roles of Atg101 in autophagy initiation

  • The crystal structure of the Atg101–Atg13 complex elucidates the function of Atg101 and sheds light on the molecular mechanisms of autophagy initiation in higher eukaryotes.

  • Syntaxin opening by the MUN domain underlies the function of Munc13 in synaptic-vesicle priming

  • Crystallographic and functional studies reveal the arch-shaped architecture of the Munc13 MUN domain and show the molecular basis for Munc13's role in synaptic-vesicle priming by mediating syntaxin-1 opening and SNARE-complex assembly.
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