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Table of Contents for this page:

  • Current Issue
  • Advanced Online Publications Articles

  • Current Issue of Nature Structural and Molecular Biology

    Nature Structural aamp; Molecular Biology - Issue - science feeds

  • An alerting structure: human orexin receptor 1

  • Structures of the human orexin receptor 1 (hOX1R) bound to a selective drug and the dual (hOX1R- and hOX2R-targeting) antagonist suvorexant reveal molecular mechanisms of selectivity in orexin-receptor subtypes.

  • X marks the spot: PRDM9 rescues hybrid sterility by finding hidden treasure in the genome

  • Three recent reports explore how PRDM9 binds to meiotic hotspots within the genome and provide compelling evidence that hotspot erosion leads to speciation.

  • USP7 is a SUMO deubiquitinase essential for DNA replication

  • USP7 deubiquitinase is now shown to prevent ubiquitination of SUMO chains of replisome proteins, thereby regulating DNA replication-fork progression and origin firing.

  • A structural ensemble of a ribosome–nascent chain complex during cotranslational protein folding

  • NMR approaches are used to probe cotranslational folding of a nascent polypeptide with two domains in Escherichia coli. The work reveals that interactions with the ribosome inhibit acquisition of the native fold by the nascent chain.

  • Inhibition of telomerase RNA decay rescues telomerase deficiency caused by dyskerin or PARN defects

  • New evidence that human telomerase RNA (hTR) degradation by EXOSC10 or DCP2 and XRN1 reduces telomerase activity when dyskerin is compromised suggests that RNA decay pathways may provide future therapeutic targets for telomere biology disorders.

  • Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors

  • Human orexin receptors (hOX1R and hOX2R) are GPCRs involved in sleep regulation. Structures of hOX1R bound to a selective antagonist or to a dual antagonist, functional assays and computational analyses reveal the basis for subtype selectivity.

  • Diverse functions of myosin VI elucidated by an isoform-specificα-helix domain

  • Structural and cellular analyses reveal that the presence of an isoform-specificα-helix in myosin VI determines whether this motor protein functions in endocytosis or cell migration.

  • Molecular basis and specificity of H2A.Z–H2B recognition and deposition by the histone chaperone YL1

  • The crystal structure of human YL1, here established as an H2A.Z-deposition chaperone, in complex with an H2A.Z–H2B dimer reveals the molecular basis for the specificity of H2A.Z recognition.

  • Structural basis of H2A.Z recognition by SRCAP chromatin-remodeling subunit YL1

  • The crystal structure of Drosophila melanogaster YL1 in complex with an H2A.Z–H2B dimer exposes a selective recognition mechanism distinct from those of other H2A.Z chaperones and suggests a hierarchical transfer mechanism mediating H2A.Z deposition.

  • Axin cancer mutants form nanoaggregates to rewire the Wnt signaling network

  • Cancer-associated point mutations in the scaffold protein Axin derail Wnt signaling and promote tumor growth through formation of nonamyloid nanoaggregates that rewire the Axin interactome.

  • Multiperspective smFRET reveals rate-determining late intermediates of ribosomal translocation

  • Monitoring ribosomal translocation from five structural perspectives with pre–steady state smFRET defines intramolecular conformational events within the EF-G–GDP–bound ribosome as rate-determining steps of directional substrate translocation.

  • Choreography of molecular movements during ribosome progression along mRNA

  • Ensemble kinetics and FRET analyses reveal the sequence of collective motions on the E. coli ribosome during translocation promoted by EF-G and allow identification of a new early forward swiveling of the SSU head.

  • An interactive environment for agile analysis and visualization of ChIP-sequencing data

  • EaSeq, a user-friendly and freely available software tool, offers fast and comprehensive ChIP-sequencing data analyses, enabling experimentalists to easily extract information and generate hypotheses from genome-wide datasets.

  • Erratum: Reappraising the effects of artemisinin on the ATPase activity of PfATP6 and SERCA1a E255L expressed in Xenopus laevis oocytes

  • Erratum: Exploiting the exploiter: a viral inhibitor stabilizes TAP for cryo-EM

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    Nature -Advance Online Publications

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    Nature Structural aamp; Molecular Biology - AOP - science feeds

  • Crystal structure of the prefusion surface glycoprotein of the prototypic arenavirus LCMV

  • The crystal structure of the GP1–GP2 complex of the prototypical arenavirus LCMV in prefusion form sheds light on the conformational changes that the arenavirus glycoprotein undergoes to cause fusion.

  • Extensive subunit contacts underpin herpesvirus capsid stability and interior-to-exterior allostery

  • Capsids from two herpesviruses (HSV-1 and PRV), imaged inside intact virions, are analyzed by cryo-EM. The maps allowed the construction of a complete model of subunit and domain organization, revealing extensive subunit contacts.

  • Long noncoding RNA LINP1 regulates repair of DNA double-strand breaks in triple-negative breast cancer

  • New data reveal that LINP1, a lncRNA overexpressed in triple-negative breast cancer, interacts with the Ku70–Ku80 complex and DNA-PKcs, thereby promoting NHEJ-mediated DNA double-strand-break repair.

  • Mammalian elongation factor 4 regulates mitochondrial translation essential for spermatogenesis

  • Genetic ablation of EF4 in mice leads to male sterility due to mitochondrial translation defects, which can be compensated for in somatic tissues by mTOR-mediated upregulation of cytoplasmic translation.

  • Structures of human ADAR2 bound to dsRNA reveal base-flipping mechanism and basis for site selectivity

  • Crystal structures of the human ADAR2 deaminase domain in complex with RNA duplexes reveal the mechanisms for ADAR2's action and explain its substrate preference. The work also provides a rationale to understand disease-related mutations.

  • Resolving individual steps of Okazaki-fragment maturation at a millisecond timescale

  • High-resolution kinetic analysis and enzyme trapping assays reveal how PCNA coordinates 5′-flap generation and processing by Pol δ and FEN1 during Okazaki-fragment maturation.

  • BTG4 is a meiotic cell cycle–coupled maternal-zygotic-transition licensing factor in oocytes

  • B-cell translocation gene-4 (Btg4) bridges interactions of translation initiation factor eIF4E and CCR4–NOT deadenylase, thus triggering decay of maternal mRNA during mouse oocyte maturation.

  • Structural basis for specific inhibition of Autotaxin by a DNA aptamer

  • SELEX selections and crystallographic analyses have allowed development of a DNA aptamer that inhibits autotaxin with high potency and specificity, and exhibits efficacy against bleomycin-induced pulmonary fibrosis in model mice.

  • Molecular basis of caspase-1 polymerization and its inhibition by a new capping mechanism

  • The CARD-only protein INCA inhibits inflammasome assembly by capping caspase-1 CARD oligomers and preventing their further polymerization.

  • SIRT6 deacetylates H3K18ac at pericentric chromatin to prevent mitotic errors and cellular senescence

  • The sirtuin family protein SIRT6 maintains pericentric heterochromatin silencing at human centromeres through deacetylation of a newly discovered substrate, H3K18, thus protecting cells against mitotic errors, genomic instability and cellular senescence.

  • Expansion of antisense lncRNA transcriptomes in budding yeast species since the loss of RNAi

  • RNA interference constrains antisense lncRNA transcriptomes, and its loss during budding yeast evolution is associated with an increase in genome-wide expression of antisense lncRNAs.

  • Structural basis for therapeutic inhibition of complement C5

  • Structural and functional analyses of a new family of tick-derived C5 inhibitors in complex with inhibitor OmCI and therapeutic antibody eculizumab reveal diverse mechanisms for inhibition and provide insight into C5 activation by C5 convertases.

  • Solid-state NMR structure of a pathogenic fibril of full-length humanα-synuclein

  • α-synuclein amyloid fibrils are associated with Parkinson's disease. SSNMR analyses now reveal the atomic structure of a pathogenic human α-synuclein fibril, providing a framework for understanding fibril nucleation, propagation and interactions with small molecules.

  • Zika virus NS1 structure reveals diversity of electrostatic surfaces among flaviviruses

  • The crystal structure of the C-terminal region of Zika virus nonstructural protein 1 (NS1) reveals a fold similar to those of other flaviviruses (dengue and West Nile viruses) but different surface electrostatic features.

  • Universality of supersaturation in protein-fiber formation

  • An analysis of previously published data on fiber formation by sickle-cell hemoglobin reveals a universal curve when delay time is plotted against supersaturation (ratio of protein concentration to solubility).
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