Nature -Advance Online Publications

Nature Structural aamp; Molecular Biology

5-Formylcytosine does not change the global structure of DNA X-ray crystallography and NMR analysis demonstrate that, contrary to previous observations, fC does not significantly alter DNA structure, thus suggesting an alternative basis for recognition of fC-DNA by epigenome-modifying enzymes. The myosin mesa and the basis of hypercontractility caused by hypertrophic cardiomyopathy mutations A working model forβ-cardiac myosin in the sequestered state and binding assays reveal interactions between the myosin head and tail that are disrupted by mutations associated with hypertrophic cardiomyopathy. Human CTP synthase filament structure reveals the active enzyme conformation The human enzyme CTP synthase forms polymeric filaments with increased catalytic activity, in contrast to the inactive filaments formed by bacterial CTP synthase. Cryo-EM and crystallographic analyses explain the structural bases for those different behaviors. Active and poised promoter states drive folding of the extended HoxB locus in mouse embryonic stem cells Homotypic interactions between active and Polycomb-repressed promoters co-occurring in the same DNA fiber, rather than CTCF occupancy, explain the 3D HoxB folding pattern. ADAR1 controls apoptosis of stressed cells by inhibiting Staufen1-mediated mRNA decay In stressed cells, the ADAR1p110 isoform is phosphorylated and translocated from the nucleus to the cytoplasm, where it protects transcripts with 3′-UTR dsRNA structures from Staufen1-mediated decay, thus suppressing cellular apoptosis. A MILI-independent piRNA biogenesis pathway empowers partial germline reprogramming MILI-mediated piRNA processing and amplification is not essential for all MIWI2 male germline reprogramming activity, indicating the existence of a MILI-independent piRNA biogenesis pathway.

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