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Table of Contents for this page:

  • Current Issue
  • Advanced Online Publications Articles

  • Current Issue of Nature Structural and Molecular Biology

    Nature Structural aamp; Molecular Biology - Issue - nature.com science feeds

  • Molecular basis of HSF regulation

  • Two structural studies provide new insights into the mechanisms regulating the DNA binding and activation of human HSF family members.

  • Exploiting the exploiter: a viral inhibitor stabilizes TAP for cryo-EM

  • Unraveling the molecular arms race between virus and host has been taken to a new level. A cryo-EM study reveals in unprecedented detail how the herpesvirus immune-evasion protein ICP47 inhibits the peptide transporter TAP.

  • Structure of a DNA enzyme

  • N6-methyladenosine–encoded epitranscriptomics

  • This Perspective highlights recent progress on the location, functions and mechanisms of N6-methyladenosine (m6A), the most abundant internal modification in eukaryotic mRNA. In particular, the authors discuss how m6A modification affects the mammalian RNA life cycle at multiple stages.

  • Replication stress: getting back on track

  • In this Review, the authors discuss emerging mechanisms of how the replication machinery of mammalian cells overcomes replication-fork obstacles, thus ensuring faithful genome duplication.

  • N6-methyladenosine in mRNA disrupts tRNA selection and translation-elongation dynamics

  • Methylation of adenosine within mRNA coding regions delays tRNA accommodation during translation and thus changes translation dynamics, which might influence protein folding.

  • Neil DNA glycosylases promote substrate turnover by Tdg during DNA demethylation

  • During oxidative DNA demethylation, Neil DNA glycosylases stimulate processing of abasic sites generated by Tdg, which excises 5-methylcytosine oxidation products generated by Tet dioxygenases, promoting restoration of unmodified cytosines via base excision repair.

  • EF4 disengages the peptidyl-tRNA CCA end and facilitates back-translocation on the 70S ribosome

  • Cryo-EM structures of EF4 with the 70S ribosome, in conjunction with functional assays, reveal insights into the mechanism of EF4-mediated tRNA back-translocation.

  • Assembly of methylated KDM1A and CHD1 drives androgen receptor–dependent transcription and translocation

  • Methylation of the lysine demethylase KDM1A and the recognition of this modification by the chromodomain helicase CHD1 control androgen-dependent gene transcription and TMPRSS2-ERG gene fusion, a common translocation event in prostate cancer.

  • Structure of human heat-shock transcription factor 1 in complex with DNA

  • Crystal structures of human HSF1 DNA-binding domain in complex with DNA and of the coiled-coil domain from a fungal ortholog provide insight into the mode of interaction of this transcription factor with DNA.

  • Structures of HSF2 reveal mechanisms for differential regulation of human heat-shock factors

  • Crystal structures of human HSF2 DNA-binding domain bound to DNA, along with biochemical and cellular analyses, offer insight into potential regulatory interactions of this transcription factor.

  • Concomitant binding of Afadin to LGN and F-actin directs planar spindle orientation

  • The adhesion molecule Afadin acts as a scaffold coordinating the cortical assembly of the cellular machinery that orients the mitotic spindle and drives planar cell division.

  • Structural basis and function of XRN2 binding by XTB domains

  • Interaction of the RNase XRN2 with PAXT-1 and related XTB domain–containing proteins is important for XRN2 function in vivo and probably serves to increase XRN2 stability in the absence of substrate.

  • Selective integrin endocytosis is driven by interactions between the integrinα-chain and AP2

  • An evolutionarily conserved YxxΦ motif present in a subset of integrin α-chains directs selective endocytosis of integrin heterodimers via interaction with the clathrin adaptor AP2, which is important for cell motility.

  • Cryo-electron microscopy structure of the TRPV2 ion channel

  • A cryo-EM structure of rabbit TRPV2 in a putative desensitized state suggests secondary-structure reorganization in S6 during channel gating.

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    Nature -Advance Online Publications

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    Nature Structural aamp; Molecular Biology - AOP - nature.com science feeds

  • Domain-swap polymerization drives the self-assembly of the bacterial flagellar motor

  • A combination of evolutionary covariance, biochemistry and SAXS analyses reveal that Escherichia coli FliG exists as a monomer in solution but forms domain-swapped polymers in assembled flagellar motors, thus leading to a thermodynamic model for self-assembly.

  • A new MCM modification cycle regulates DNA replication initiation

  • Complementary biochemical and genetic analyses reveal that SUMOylation of the six subunits of the MCM2–7 DNA helicase inhibits CMG formation, thereby negatively regulating DNA replication initiation in budding yeast.

  • Structure of the eukaryotic replicative CMG helicase suggests a pumpjack motion for translocation

  • A 3.7- to 4.8-Å cryo-EM structure of the yeast CMG complex resolves two Mcm2–7 helicase conformations that may drive complex translocation and reveals an Mcm5-subunit domain inserted into the central channel, thus supporting a steric-exclusion model of DNA unwinding.

  • Crystal structures reveal the molecular basis of ion translocation in sodium/proton antiporters

  • New crystal structures of the NapA antiporter in both outward- and inward-facing conformations provide evidence for an elevator-like ion-translocation mechanism in sodium/proton exchangers.

  • The bacterial dicarboxylate transporter VcINDY uses a two-domain elevator-type mechanism

  • ‘Repeat swap’ modeling of the outward-facing conformation and biochemical analyses show that the bacterial VcINDY symporter uses an elevator-type mechanism for substrate transport across the cell membrane.

  • A U1 snRNP–specific assembly pathway reveals the SMN complex as a versatile hub for RNP exchange

  • The higher abundance of U1 among snRNPs is explained by the identification of an additional mode of assembly: RBP U1-70K bridges pre-U1 to SMN–Gemin2–Sm, thus establishing a Gemin5-independent assembly pathway.

  • EF4 disengages the peptidyl-tRNA CCA end and facilitates back-translocation on the 70S ribosome

  • Cryo-EM structures of EF4 with the 70S ribosome, in conjunction with functional assays, reveal insights into the mechanism of EF4-mediated tRNA back-translocation.

  • Selective integrin endocytosis is driven by interactions between the integrinα-chain and AP2

  • An evolutionarily conserved YxxΦ motif present in a subset of integrin α-chains directs selective endocytosis of integrin heterodimers via interaction with the clathrin adaptor AP2, which is important for cell motility.

  • Structural basis and function of XRN2 binding by XTB domains

  • Interaction of the RNase XRN2 with PAXT-1 and related XTB domain–containing proteins is important for XRN2 function in vivo and probably serves to increase XRN2 stability in the absence of substrate.

  • Cryo-electron microscopy structure of the TRPV2 ion channel

  • A cryo-EM structure of rabbit TRPV2 in a putative desensitized state suggests secondary-structure reorganization in S6 during channel gating.

  • Concomitant binding of Afadin to LGN and F-actin directs planar spindle orientation

  • The adhesion molecule Afadin acts as a scaffold coordinating the cortical assembly of the cellular machinery that orients the mitotic spindle and drives planar cell division.

  • N6-methyladenosine in mRNA disrupts tRNA selection and translation-elongation dynamics

  • Methylation of adenosine within mRNA coding regions delays tRNA accommodation during translation and thus changes translation dynamics, which might influence protein folding.

  • Assembly of methylated KDM1A and CHD1 drives androgen receptor–dependent transcription and translocation

  • Methylation of the lysine demethylase KDM1A and the recognition of this modification by the chromodomain helicase CHD1 control androgen-dependent gene transcription and TMPRSS2-ERG gene fusion, a common translocation event in prostate cancer.

  • Neil DNA glycosylases promote substrate turnover by Tdg during DNA demethylation

  • During oxidative DNA demethylation, Neil DNA glycosylases stimulate processing of abasic sites generated by Tdg, which excises 5-methylcytosine oxidation products generated by Tet dioxygenases, promoting restoration of unmodified cytosines via base excision repair.

  • Structures of HSF2 reveal mechanisms for differential regulation of human heat-shock factors

  • Crystal structures of human HSF2 DNA-binding domain bound to DNA, along with biochemical and cellular analyses, offer insight into potential regulatory interactions of this transcription factor.

  • Structure of human heat-shock transcription factor 1 in complex with DNA

  • Crystal structures of human HSF1 DNA-binding domain in complex with DNA and of the coiled-coil domain from a fungal ortholog provide insight into the mode of interaction of this transcription factor with DNA.
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