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Jean-Yves Sgro
Inst. for Mol.Virology
731B Bock Labs
1525 Linden Drive Madison, WI 53706
virusworld
Topographical Maps

topo_map

Topographical maps represent one "face" of the 60 faces of the icosahedron. The symmetryaxes would allow to reconstruct a complete icosahedral viral particle from one face.

figure 1

The topography is illustrated by coloring surface regions as a function of the distance to the center of the virus. That distance can be the radius(distance to the center) or a "Z" value (distance to a plane parallel to the icosahedral face).

figure 2

The surface matrix is calculated with Vsurf (Rossmann and Palmenberg (1988) and rendered into Deltagraph on a Macintosh.

Images

File, general structure reference, PDB entry
T=1,T=3,P=3 sketch
Canine Parvo Virus, Tsao et al. (1991) 2DPV
Foot & Mouth Disease Virus, (Q1 BFS 1860) Acharya et al. (1989) 1BBT
Mengo Virus (pH 4.6), Luo et al. (1987), 1MEC
   Mengo Virus* (pH 4.6), Luo et al. (1987), 1MEC
Polio Virus Type 1 Mahoney, Hogle et al. (1985), 2PLV
Polio Virus Type 3 Sabin, Filman et al. (1989), -
Rhinovirus 14, Rossmann et al. (1985), 4RHV
Rhinovirus 16, Oliveira et al. (1993), -
Rhinovirus 1a, Kim et al. (1990), 1R1A
Theilers Virus (BeAn Strain, pH 8.4), Luo et al. (1992), 1TMF

References

Program Vsurf

Rosssmann MG, Palmenberg AC (1988) Conversion of the putative receptor attachment site in picornaviruses. Virology 164, 373-382.

Additional reference:
Chapman MS (1993) Mapping the surface properties of macromolecules. Protein Science 2, 459-469

Virus structures

Acharya R., Fry E., Stuart D., Fox G, Rowlands D., Brown F. (1989) The three-dimensional structure of foot-and-mouth-disease virus at 2.9? resolution. Nature 37,709-716

Hogle J.M., Chow M, Filman DJ (1985) Three-dimensional structure of poliovirus at 2.9? resolution. Science 229,1358-1365

Kim S, Beoge U, Krishnaswamy S, Minor I, Smith TJ, Luo M, Scraba DG, Rossmann MG (1990) Conformational variability of a picornavirus capsid: pH-dependent structural changes of Mengo virus related to its host receptor attachment site and disassembly. Virology 175, 176-190.

Luo M, Vriend G, Kamer G, Minor I, Arnold E, Rossmann MG, Boege U, Scraba DG, Duke GM, Palmenberg AC (1987) The atomic structure of mengo virus at 3.0? resolution. Science 235, 182-191.

Luo M., He C., Toth K.S., Zhang C.X., Lipton H.L. (1992) The three-dimensional structure of Theiler's murine encephalomyelitis virus (BeAn strain). Proc.Natl. Acad. Sci. USA 89, 2409-2413. (contains a topographical map: [Figure 2. color.] )

Filman DJ, Syed R, Chow M, Macadam AJ, Minor PD, Hogle JM (1989) Structural factors specificity in type 3 poliovirus. EMBO J 8, 1567-1579.

Oliveira MA, Lee W-M, Zhao R, Kremer M, Minor I, Rueckert RR, Diana GD, Pevear DC, Dutko FJ, McKinlay MA,, Rossmann MG (1993) The structure of human rhinovirus 16. Structure. 1,---,---. Submitted 1993.

Rotbart, H. A. and Kirkegaard K. (1992) Picornavirus pathogenesis: viral access, attachment and entry into susceptible cells. Semin. Virol. 3, 483-499. (contains a topographical map: [Figure 3 (A-F). color.] )

Rossmann MG, Arnold E, Erickson JW, Frankenberger EA, Griffith JP, Hecht H-J, Johnson JE, Kamer G, Luo M, Mosser AG, Rueckert RR, Sherry B, Vriend G (1985) Structure of human common cold virus and functional relationship to other picornaviruses. Nature 317, 145-153.

Tsao J., Chapman M.S., Agbandje M., Keller W., Smith K., Wu H., Luo M., Smith T. J., Rossmann M.G., Compans R.W. and Parrish C. (1991) The three-dimensional structure of canine parvovirus and its functional implications. Science 251, 1456-1464. (contains a topographical map: [Figure 1.. color.] )

Source

Compiled July 1993 by:
Jean-Yves Sgro, Ph.D., Senior Scientist, Institute for Molecular Virology, Robert Bock Laboratories, University of Wisconsin-Madison, 1525 Linden drive, Madison Wi 53706 -USA.

Tel: 608-262-7464

Fax: 608-262-7414

e-Mail: jsgro@wisc.edu

Files are supplied "as is" and are screen captures of the original drawings which are polygon based images within Canvas 3.03 or MacDraw Pro (and are much bigger in byte size!). Files can be redistributed but not sold except for the price of medium and aknowledgment of source as well as the README file are provided.

(*) This images was created with program GRASP directly on Silicon Graphics. View is along the icosahedral 2-fold axis.